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FPTQ B

CAS No. 864863-72-9

FPTQ B ( —— )

产品货号. M35294 CAS No. 864863-72-9

FPTQ 是一种有效的 mGluR1 拮抗剂,抑制人和鼠的 IC50 值分别为 6 nM 和 1.4 nM。FPTQ 具有抗氧化、抗炎作用。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
2MG ¥594 有现货
5MG ¥912 有现货
10MG ¥1316 有现货
25MG ¥2557 有现货
50MG ¥3456 有现货
100MG ¥4483 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    FPTQ B
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    FPTQ 是一种有效的 mGluR1 拮抗剂,抑制人和鼠的 IC50 值分别为 6 nM 和 1.4 nM。FPTQ 具有抗氧化、抗炎作用。
  • 产品描述
    FPTQ is potent mGluR1 antagonist with IC50 values of 6 nM and 1.4 nM for human and mouse mGluR1 respectively. FPTQ has anti-oxidant and anti-inflammatory effects in vitro and in vivo.
  • 体外实验
    FPTQ (0.5-10 μM) does not shows any cytotoxicity was not observed at 0.5, 1, 5, and 10 μM in RAW264.7 macrophage cells.FPTQ (1-20 μM; 24 hours) reduces LPS-induced NO production at > 1 μM FPTQ, and at 10 μM, FPTQ treatment causes a 31% anti-oxidant effect in RAW264.7 macrophage cells.FPTQ (1-20 μM; 24 hours) dramaticly decreases LPS-induced expression levels of IL-1β and Il-6. At a concentration of 10 μM, FPTQ causes a 27% and 44% reduction in the mRNA expression of IL-1β and Il-6, respectively in RAW264.7 macrophage cells.RT-PCR Cell Line:RAW264.7 macrophage cells Concentration:1, 10, or 20 μM Incubation Time:24 hours Result:Decreased IL-1β and IL-6 mRNA expression
  • 体内实验
    FPTQ (5-20 μM) decreases the number of neutrophils migrating to the amputation site in zebrafish larvae by tail amputation. In the tailfin wound method, the number of neutrophils collecting at the wound site also decreases in a dose-dependent manner in zebrafish.In a LPS-induced inflammation zebrafish model, LPS solution is injected into the yolks of Tg(mpx:EGFP)i114 zebrafish larvae and exposed the zebrafish larvae immediately to FPTQ treatment.FPTQ (20 μM; 4 hours) significantly decreases the fluorescent neutrophils after yolk injection and has an anti-inflammatory effect during the early phase of inflammation.
  • 同义词
    ——
  • 通路
    Neuroscience
  • 靶点
    GluR
  • 受体
    GluR
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    864863-72-9
  • 分子量
    305.31
  • 分子式
    C17H12FN5
  • 纯度
    >98% (HPLC)
  • 溶解度
    In Vitro:?DMSO 中的溶解度 : 33.33 mg/mL (109.17 mM; 超声助溶 )
  • SMILES
    Cc1c(nnn1-c1cccnc1F)-c1ccc2ncccc2c1
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Fujinaga M et al. Synthesis and evaluation of 6-[1-(2-[(18)F]fluoro-3-pyridyl)-5-methyl-1H-1,2,3-triazol-4-yl]quinoline for positron emission tomography imaging of the metabotropic glutamate receptor type 1 in brain. Bioorg Med Chem, 2011 Jan 1, 19(1):102?
产品手册
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